Botanical guide
Ashwagandha
Some ashwagandha extracts may help with stress and sleep, but products are not interchangeable. KSM-66 uses root only; Sensoril uses root and leaf. Compare the extract, daily amount and safety considerations before choosing a product.
Compare products ↓What is ashwagandha?
Ashwagandha (Withania somnifera) is a plant used traditionally in South Asia. Supplements usually contain root powder, root extract or root-and-leaf extract. Concentrated extracts can be standardised for naturally occurring compounds called withanolides, a group of steroidal lactones.
What might ashwagandha help with?
Some short-term studies suggest that particular ashwagandha extracts may help with perceived stress and sleep. Findings depend on the extract and study population; the name “ashwagandha” alone does not identify a clinically equivalent product.
Exercise-related outcomes have also been investigated, but evidence is not sufficient to promise broad benefits for every preparation. It is more useful to match an extract to relevant human research than to choose the largest milligram number.
What does the research say about stress, cortisol and sleep?
Small trials suggest benefits, rather than a universal effect
NIH's Office of Dietary Supplements describes several short trials reporting improvements in stress or sleep measures. Studies use different root or root-and-leaf extracts, doses and participants; many are small. NCCIH considers evidence for anxiety less clear.
For example, a 2012 placebo-controlled trial enrolled 64 adults with chronic stress and tested 300 mg of a concentrated root extract twice daily for 60 days. Stress scores and serum cortisol fell more in the extract group. This is a study regimen, not a personal dose recommendation.
Does lower cortisol mean better health?
Not necessarily. Cortisol is a normal hormone, and a study finding does not show that everyone should try to lower it. The trial does not establish treatment for a hormonal disorder, nor prove that a different extract will produce the same result.
Is ashwagandha safe to take every day?
Short-term tolerability is better studied than long-term safety. NIH sources describe use for up to about three months, but this is not a guaranteed safe period for every person or preparation. Continuous use over many months or years remains insufficiently understood.
Do you need to cycle it or take breaks?
There is no established evidence-based cycling schedule that makes long-term use safe. A planned week off does not resolve uncertainty about the extract, dose or individual risk. Reassess whether it is helping rather than treating it as an indefinite daily essential.
Side effects and who should avoid it
Possible effects include stomach upset, diarrhoea and drowsiness. Rare liver injury has been reported. Avoid during pregnancy and breastfeeding. Thyroid or autoimmune disease, upcoming surgery and hormone-sensitive prostate cancer require particular caution; seek professional advice rather than self-selecting a product.
Interactions may involve thyroid hormones, sedatives, anticonvulsants, immunosuppressants, and diabetes or blood-pressure medicines. Stop use and seek medical advice for yellow skin or eyes, dark urine or marked unexplained nausea or fatigue, especially if you have liver disease.
What exactly is in the capsule?
Common ashwagandha formats
KSM-66 vs Sensoril: what is the difference?
KSM-66 is a root-only extract; Sensoril combines root and leaf. They also differ in standardisation and the amounts used in studies. Neither name alone makes a finished supplement the better choice.
| Feature | KSM-66® | Sensoril® |
|---|---|---|
| Plant material | Root only | Root and leaf |
| Typical label standardisation | Around 5% withanolides | Often at least 10% withanolide glycosides; check the exact label |
| Research context | Root-extract trials include stress and sleep outcomes | Root-and-leaf trials include stress and sleep outcomes |
| How to compare | Match the named extract, daily serving and relevant trial. Percentages alone do not establish dose equivalence. | |
Is 10% twice as strong as 5%?
It is not a reliable clinical comparison. Labels can refer to different groups of compounds and analytical methods. Even when a percentage helps calculate a declared constituent amount, it does not establish twice the benefit, or that a smaller capsule can replace a larger one.
What about Shoden?
Shoden® is another concentrated root-and-leaf extract with its own standardisation and research. Keep it separate when comparing formulations; do not convert between branded extracts using milligrams alone.
For a root-only preference, identify products that actually name the root extract. For a Sensoril product, confirm the branded ingredient and daily serving. Check added actives too: black pepper, L-theanine or other ingredients make the whole formula different.
Compare ashwagandha extracts and daily amounts →What should you compare?
Plant part
Root only or root + leaf.
Extract / brand
KSM-66®, Sensoril®, Shoden® or a non-branded standardised extract.
Withanolide standardisation
A useful concentration clue when stated, but not an effectiveness score.
Daily serving
Compare the manufacturer's full recommended daily amount, not one capsule in isolation.
Other ingredients
Some products include black pepper extract, L-theanine, magnesium or other compounds.
Vegan status & format
Capsules and softgels differ in shell ingredients and convenience.
Product comparison
Compare ashwagandha supplements
Compare daily amount, amount per unit, serving, extract, plant part, standardisation, format, other active ingredients and vegan suitability.
Default order: labelled minimum daily ashwagandha amount, lowest to highest; equal amounts alphabetically. This is not an effectiveness ranking.
| Product | Daily amount | Amount / unit | Recommended daily serving | Extract | Plant part | Standardisation | Format | Other active ingredients | Vegan |
|---|---|---|---|---|---|---|---|---|---|
| Swanson Sensoril® AshwagandhaView product ↗ | 125 mg | 125 mg | 1 capsule daily | Sensoril® | Root + leaf | Min. 0.4% withanolide glycosides | Capsule | — | Not confirmed |
| Life Extension Optimized AshwagandhaView product ↗ | 250 mg | 125 mg | 1 capsule twice daily on an empty stomach | Sensoril® | Root + leaf extract | 32% oligosaccharides; 10% withanolide glycoside conjugates | Vegetarian capsule | — | Vegetarian; vegan not confirmed |
| Sports Research AshwagandhaView product ↗ | 500–1,000 mg | 250 mg | 2 softgels 1–2× daily with food | Shoden® + ashwagandha powder | Root + leaf | 120 mg Shoden® in 2-softgel serving; Shoden standardised extract | Vegan softgel | BioPerine® black pepper extract, coconut MCT | Yes |
| NOW Foods KSM-66 Ashwagandha®View product ↗ | 600 mg | 600 mg | 1 capsule daily | KSM-66® | Root | KSM-66® full-spectrum root extract | Veg capsule | — | Yes |
| NutraBio KSM-66® AshwagandhaView product ↗ | 600 mg | 600 mg | 1 capsule daily | KSM-66® | Root | Standardised to 5% withanolides | Capsule | — | Vegetarian |
| NOW Foods Ashwagandha Standardized ExtractView product ↗ | 900–1,350 mg | 450 mg | 1 capsule 2–3× daily | Standardised extract | Root + leaf | Min. 2.4% total withanolides | Veg capsule | — | Yes |
EU health claim details
Authorised health claims
No EU-authorised health claim is listed for this ingredient.
On-hold botanical claims
Pending EU-level consideration — not final authorised claims● Stress, relaxation and mental well-being.Ashwagandha · Submitted botanical claim theme
On hold / pending EU-level consideration
Ingredient
Withania somnifera (Ashwagandha)
Claim ID
2183
EFSA question
EFSA-Q-2008-2916
Regulatory note
This is not a final EU-authorised health claim.
● Cardiovascular health.Ashwagandha · Submitted botanical claim theme
Beneficially affects the heart and cardiovascular system.
Ingredient
Withania somnifera (Ashwagandha)
Claim ID
2503
EFSA question
EFSA-Q-2008-3236
Status
On hold — not a final EU-authorised health claim.
● Adaptogenic properties.Ashwagandha root · Submitted botanical claim theme
Ashwagandha has adaptogenic properties.
Ingredient
Ashwagandha root (Withania somnifera)
Claim ID
3251
EFSA question
EFSA-Q-2008-3983
Status
On hold — not a final EU-authorised health claim.
● Physical and mental capacities.Ashwagandha · Submitted botanical claim theme
Helps to maintain physical and mental capacities in cases of weakness, exhaustion, tiredness and loss of concentration; nerve tonic.
Ingredient
Withania somnifera
Claim ID
3657
EFSA question
EFSA-Q-2008-4380
Status
On hold — not a final EU-authorised health claim.
● Mental balance, stress and sleep.Ashwagandha root · Submitted botanical claim theme
Resistance to stress, mental balance, mental function, onset of sleep, learning, memory, recall and emotional stability.
Ingredient
Withania somnifera root
Claim ID
4194
EFSA question
EFSA-Q-2008-4905
Status
On hold — not a final EU-authorised health claim.
● Energy and vitality.Ashwagandha · Submitted botanical claim theme
On hold / pending EU-level consideration
Ingredient
Withania somnifera (Ashwagandha)
Claim ID
4195
EFSA question
EFSA-Q-2008-4906
Regulatory note
This is not a final EU-authorised health claim.
● Respiratory health.Ashwagandha root · Submitted botanical claim theme
Helps maintain the health of the respiratory system.
Ingredient
Withania somnifera root
Claim ID
4196
EFSA question
EFSA-Q-2008-4907
Status
On hold — not a final EU-authorised health claim.
● Rejuvenation.Ashwagandha root · Submitted botanical claim theme
Has a general rejuvenating effect.
Ingredient
Withania somnifera root
Claim ID
4197
EFSA question
EFSA-Q-2008-4908
Status
On hold — not a final EU-authorised health claim.
● Reproductive health.Ashwagandha root · Submitted botanical claim theme
Female reproductive organs, strength in pregnancy, male sexual function, sperm mobility and sperm count.
Ingredient
Withania somnifera root
Claim ID
4198
EFSA question
EFSA-Q-2008-4909
Status
On hold — not a final EU-authorised health claim.
● Skin health.Ashwagandha root · Submitted botanical claim theme
Helps maintain the health of the skin.
Ingredient
Withania somnifera root
Claim ID
4199
EFSA question
EFSA-Q-2008-4910
Status
On hold — not a final EU-authorised health claim.
Sources & regulatory details
Sources & further reading
- NIH ODS: ashwagandha — stress, anxiety, sleep and safety ↗
- NIH NCCIH: ashwagandha usefulness, interactions and safety ↗
- Chandrasekhar et al., 2012: placebo-controlled root-extract trial in stressed adults ↗
- KSM-66 manufacturer: root-only ingredient description ↗
- Kerry: Sensoril root-and-leaf ingredient technical information ↗
- Nutrisan: example Sensoril label and withanolide-glycoside standardisation ↗
- EFSA: Article 13 health claims ↗